Intrauterine Insemination or In-vitro Fertilization?

As is known, the first approach for couples who do not have any evincible problem, in other words, were diagnosed with idiopathic infertility is intrauterine insemination for several times and then in-vitro fertilization treatments if no pregnancy occurs.

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Medicana International Istanbul IVF Center
We offer a wide range of Assisted Reproductive Technologies includingIVF and ICSI (Intracytoplasmic Sperm Injection), Embryo and SpermCryopresevation, Intrauterine inseminations (IUI), ovulation induction, Co-Culture (Artificial Uterus). Also other micromanipulation methods (assisted hatching, defragmentation, blastomer biopsy), epididymal or testicular sperm aspiration/extraction (PESA, TESA, TESE or micro TESE) are carried out in our laboratory.We generally prefer day 5 (blastocyct) transfer with high pregnancy rates, potential for very low multiple birth risks.. You will have the benefits of well-trained and English-speaking physicians and support personnel and what's more, you will pay just half the cost of comparable WesternIVF clinics.Let us help you to have a healthy new baby as soon as possible with no waiting list. We pride ourselves on giving this opportunity to even the most challenging of patients. opportunity to even the most challenging of patients.
Web: http://www.turkey-ivf.com/ Phone: +90 212 867 79 18
Our Package Prices are as follows;
Option 1
IVF / ICSI Package
İncluding all exams, ultrasound, blood tests £ 1500
Freezing Excess Embriyos ( With Vitrification ) £ 250
Assiste Hatching ( With Laser) Included
IMSI ( In severe male factor cases) Included

All cycle costs are package costs and include all the ultrasound scans, anaesthetic charges, doctor's fees and post-op recovery where applicable.
At the time of egg collection, if there are no eggs or failed fertilisation, we refund £ 300 for cancellation of embryo transfer
Pregnancy scans are charged separately.
Medication costs are charged separately and can vary from patient to patient. Patients are requested to buy the drugs from the pharmacy themselves

Option 2

£ 2250 : Option 1 + all drugs and medications until embriyo transfer

Option 3

£ 3250 : Option 2 + freezing the extra embryos and also a 20 night accommodation in a flat and airport transfers. Flat is fully furnished and very near to our Hospital (in walking distance).

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What are my chances of success from IVF?

Success rates of IVF treatment cycles depend on certain variables, which include the age of the woman,  number of eggs produced after stimulating the ovaries with fertility drugs, quality of the semen, number of good quality resulting embryos, and the number of transferred embryos.

IVF success rates are higher for women under 35. The success rates of in vitro fertilization can be increased by combining IVF with other treatment methods. IVF is often performed with ICSI to increase the success rates of fertilization during the IVF process.  

What is IVF?

What is IVF?

IVF or In Vitro Fertilisation, refers to the most widely spread method of Assisted Reproductive Technology (ART). The Latin term 'in vitro' means anything that is cultivated outside a living organism - literally“in a glass.” Early biological experiments involving the cultivation of tissues outside their living organisms, were carried out in glass containers such as test tubes, petri dishes and beakers, hence the term “test tube baby.” 

During in vitro fertilisation, collected eggs are fertilized outside the womb and resulting embryos are transferred into the uterus of the woman. In the case of IVF with Egg Donation, the eggs of the donor are used for fertilization outside of the womb, and then the resulting embryo is transferred into the uterus of the female recipient.

What is IVF with ICSI (Intracytoplasmic Sperm Injection)?

The test-tube fertilization process has been replaced with ICSI (intracytoplasmic sperm injection) because of its proven success rates.

ICSI is the process by which one sperm is inserted into one egg, resulting in one embryo.

ICSI is more effective than IVF with a higher success rate because the sperm is injected directly into the cytoplasm of the egg stimulating the fertilization process.

ICSI requires only one sperm making it a successful treatment method for males with a low sperm count or poor quality sperm. 

SEVEN IMPORTANT FACTS YOU SHOULD KNOW ABOUT IVF AND THE CENTERS

The drive to have a family is a very strong natural urge in most individuals or couples, and its due to this that IVF treatments will continue to be an avenue for those in need of it, even in the face of many unanswered questions. When considering this as an avenue to explore or go down, one should know the answers of at least some of the main questions regarding IVF procedures and centers. Here are some examples..

1. What is the real success rate for IVF ?

Centres usually declare their success rates to be between 40 and 60 % per standard trial. However, in most circumstances what can influence or determine your success as an individual is you yourself. Each individual couple's chance of success depends on a number of varying factors such as age, cause of infertility and lifestyle etc. In general, for women in age groups below 35 years, each IVF trial has a success of 50 %. This significantly decreases over the age of 40 years, and for women at and over the age of 45 years, the chance is below 5% (with some exceptions).

It must be remembered however, that 'chance' always plays an important role in success. Our experience over the years has shown that for the vast majority of those who resisted and continued forging their way forward without losing their hope or confidence usually ended up with the joy of being hande d their babies at the end. Having said that, and regarding persistence, it's worth noting that if a couple or individual do not obtain success after three attempts in the same centre, then perhaps it's best attempting treatment at other centers. This is less to do with the failure of original centre, but more to do with enabling the couple or individual to make a psychological change.

2. Is IVF really expensive as they demand ?

Success certainly comes first, but the financial burden on the patient is often so great that many couples feel that they can only afford one cycle and therefore face the added stress of trying to maximize their one and only chance to conceive in that cycle, or get pregnant on the first try.

If you look at IVF prices in developed countries, it ranges between $10,000- $15,000 in US and 4500-5000GBP in UK per cycle. Besides, these prices do not cover the drug expenses and most centres charge the techniques ICSI, AHA, blastocyst culture etc. additionally. I recommend evaluating experienced centres with at least 50 cycles per month and over, to compare costs and make your selection then. On the other hand, countries like Turkey has affordable prices with high success rates. Expenses can be minimised to one-third of the high costs mentioned above and combining your medical treatment with a vacation in these countries is quite possible.

3. Is it harmful for my health ?

Every patient who is considering using IVF probably asks herself this question before she starts treatment. IVF treatment has been practiced for more than 30 years all over the world. Remember that more than four million IVF babies have been born since the earliest IVF successes in 1978. Lots of investigations have been carried out on the fact that IVF is a safe procedure when performed carefully. Today, as treatment is carried out by an experienced physician in a experienced centre, hardly a serious problem arise. Of course, as in any attempt to treat, unexpected problems and complications may occur in the rate of 1-2 %. These problems can be solved by a very large extent on careful observation and experience. The most common problem is the collection of fluid in the abdomen, bloating, excessive arousal table presenting the findings of the need for hospitalization called hyperstimulation syndrome and is about 1-2 % in experienced centres. Myths like IVF causes cancer are not at all true or based on medical findings .

4. You cannot change the age and capacity of your ovaries.

Every woman is most fertile between the ages of 20 and 30. Fertility starts to decline significantly from the age of 35. The decline in number of eggs with age is an important issue in IVF. However, egg quality and fertilization rates are also reduced from 35 years of age. There are several tests to help you to comment on that. AMH blood test (AMH) is a marker for ovarian reserve and provide information on the number of eggs to be obtained but not about the quality of the eggs. It is an indirect way of evaluating how well the ovaries are working.
Nature behaves differently in different individuals. So whilst on one hand one woman may have a wealth of ovarian capacity, another woman may unfairly suffer from the onset of menopause at an early age. The same situation is also true for men. Some may have hundreds of millions of sperm in their counts whilst some others may have very low or even none existent sperm in their counts. Unfortunately based on such a genetic characteristics, there is no specific treatment can be done. Remember that, you cannot produce new eggs and sperms, but in vitro fertilization treatment uses what exists. Perhaps this fact is subject to change with the development of stem cell therapies in the near future. We hope that this process will not take too long.

5. There is also physical and emotional cost of IVF treatment.

The majority of couples describe the IVF experience as financialy, physically and emotionally demanding. Physical side effects can include headaches, insomnia, bloating, fatigue and emotional fluctuations. Many also find the IVF experience stressful as they go through the painful process of waiting for the result. Reputable clinics offer specially trained psychological counselling services to help people through the emotionally challenging aspects of IVF. Of course, not every couple is requiring this services. In this regard, note that you are entitled to receive support and be ready for some amount of stress.

6. There is no guarantee.

Approximately four million children have been born worldwide as a result of in vitro fertilization treatments. It is a highly efficient technology to have a baby when the other treatment modalities are failed. According to statistics, around 85% of pregnancy rate reached after 3 attempts. However, with a good-quality embryo transfer in the best conditions, pregnancy rate is 50-55% per trial. In addition, miscarriage may occur in up to 10-15% in the age of 35. For a young lady trying IVF, take-home baby rate of a single embryo transfer in the optimum conditions for each trial is about 40 % . When much higher figures in the first interview is given to you, you should think about reliability of that centre.

IVF is a highly effective treatment in overcoming many causes of infertility such as low-sperm count, blocked fallopian tubes and PCOS. However, there are no guarantees. In fact, it is known that half of the people who try IVF will not be successful for each trial.

7. When should I give up?

In theory, as long as eggs from woman and the sperm from the man can be obtained and the transfer performed, the couple has a chance of pregnancy. However, if female age is close to 45, with three or more failed attempts, only poor quality embryos hardly obtained despite high-doses of drugs, and you start to get in trouble financially, sit down with your partner and think again.

Should you go on trying even your doctor say so ?

Doctors may be reluctant to stop treatment because they don’t want to accept “failure” on their part as a care-provider or they may feel that part of their job is to remain eternally hopeful and optimistic for you. The bottom line is that this is your and your partners decision.

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  Associate Prof.Dr. Selman Lacin

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ivf cost

OUR SUCCESS RATES IN MEDICANA INTERNATIONAL HOSPITAL IVF CENTER

Publication of pregnancy rates allows for comparisons between different clinics. 
Rates published by individual fertility centers should be considered carefully, as some centers set strict patient criteria in order to maintain seemingly superior pregnancy rates.

Our expertise is reflected in the success rates of Medicana International Istanbul, which are comparable to the best programs in the World. We are proud of our success rates and provide our cumulative pregnancy success rates in the following format.

Woman’s Age	Pregnancy Rate
30 or younger	68 %
30 - 35	57 %
35 - 40	40 %
41 - 43	27 %
43 - 45	12 %

ivf cost

IVF Processes in Turkey

Supression Of The Hormones

During the program, to get an appropriate response from the drugs, untimely and irregular effects (e.g. ovulation) of the hormones that your body secretes, have to be blocked. Generally, the drugs which would suppress the hormones are started on the 2nd or 21st day of the menstruation. These drugs are applied subcutaneously (under skin) once a day.

At the end of this period which normally lasts 1 to 3 weeks, the hormone levels are evaluated with blood analysis. This period can be prolonged if the hormones are not suppressed. In %5 of the patients, the program can be canceled if their hormones are not suppressed. These patients can restart to the program in their next menstrual cycle.

Short protocol: Hormone treatment is started on the 2nd day of the menstruation. The drugs are used to suppress untimely and irregular effects (e.g. ovulation) of the hormones that your body secretes. In this protocol, both the time and the amount of medication are shorter.

Induction Of The Ovaries

When the hormone levels reach the desired level, hMG (LH + FSH) or pure FSH are used are injected intramusculary or subcutaneously. Injections have to be done everyday at the same time. Additionally, the numbers of follicles are evaluated by ultrasound. The time of follicle development varies from 1 to 3 weeks depending on the response of the ovaries. %10 of patients are cancelled, because their ovarian response to the drugs is not adequate. This decision is made with the approval of the couple. Those who do not have adequate response, can reattend the program with the necessary follow-up and different drug protocols

Ultrasound Follow-Up

Vaginal ultrasound examinations are performed. Because it provides more detailed information compared to the abdominal ultrasound and saves you from discomfort because full bladder is not necessary. Follicles are liquid-filled sacs which are seen as dark colored, oval shapes under ultrasound and are thought to have oocyte inside. As the lubricant gel used is water-based, it does not have any side effects and does not stain your clothing. 

Hormone Follow-Up

Hormone levels are traced by obtaining blood samples on certain days before beginning to use ovary stimulants. You will be informed in advance for such examinations.

Since laboratory examinations are initiated after obtaining blood samples from all patients, personal delays will affect all patients called on that day. For this reason, you are asked to be careful for timely fulfillment of your appointment for blood sampling or ultrasound examination.

HCG Injection

When the follicle number and size, hormone level and the endometrium reaches the desired level, human corionic gonodotropin (hCG), is injected intramusculary to mature the eggs to trigger ovulation. 36 to 40 hours following the hCG injection, ovulation occurs. In IVF procedure, eggs are retrieved by emptying the follicles prior ovulation. As timing is very important, you have to pay maximum attention to follow the given information about hCG injection. On the hCG injection day, you will be explained and given a form explaining how you should get your injection done at a specific hour after 8 pm.

Egg Retrieval-Oocyte Pick Up

On the day of oocyte pick-up, please come to the hospital in the morning with your spouse, with empty stomach (avoid eating, drinking and smoking 6 hours before oocyte pick-up).

First, a sperm sample will be taken from your husband (in certain cases if necessary, sperms will be extracted from testicles with operation). Oocyte pick-up will be performed in the operating room under sterile conditions. During this procedure, you will be given mild anesthesia for a painless and comfortable operation. The egg retrieval is done with a needle guided by vaginal ultrasound and an aspiration system. During and following anesthesia, pain complaints are rare. The same day, you will be discharged from the hospital after the doctor visit and information will be given about the egg number and the following processes. Usually the whole procedure takes 1-2 hours but we recommend that you spare your whole day to the IVF and do not make any other plans for that day. Rarely, no eggs can be retrieved from the follicles. The most common reason for that is not getting your hCG injection in the right time or right manner.

Progesteron Application

Starting from the day of egg retrieval, vaginal gel should be used. This application should continue until your doctor asks you to stop. Therefore do not stop your medication without consulting your doctor.

Embryo Transfer

Not every retrieved egg yield to an embryo. Embryo transfer might be canceled if fertilization failure or inadequate embryo formation occurs. For this reason, you should call us the next day of retrieval and get information about the fertilization. In the following days, appropriately developed embryos will be transferred to the uterus. As this procedure is done as a normal vaginal examination, there is no need for anesthesia. We recommend that you have a light breakfast before you come to the center. Previously decided number of embryos will be transferred into the uterus with a plastic catheter in gynecological examination position. This procedure has to be done with full bladder. You can be discharged following this process, after a short rest. Again your IVF doctor will give you information about ET and the days following it. We recommend a home rest the same day but the following day you can go back to your routine life style.

Pregnancy Test

Pregnancy test will be performed on the 12th day following the ET by detecting beta-hCG hormone level in blood. A pregnancy can also occur despite the bleeding.

For this reason this test has to be done. Depending on the test result, about 10 days later, vaginal ultrasound examination is needed to see fetal sac (embryonic sac). 

Application

To attend the IVF program, you have to have a first consultation with your IVF doctor. Please note the following correspondence numbers and address to make an appointment:
Phone : +90 212 867 79 18 / +90 212 867 75 00

It is important to come to the first visit to the doctor as a couple and to bring all previous medical records with you.

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