31 Mayıs 2013 Cuma

Pre-implantation Genetic Diagnosis (PGD)

Pre-implantation genetic diagnosis or PGD is a technique of preventing certain inherited conditions from being passed on to a couple's child. The process involves a thorough checking of the embryo's genes during an IVF cycle.

When is PGD recommended?

This procedure is recommended under the following conditions:

  • The couple has had abortions in the past because the baby was found to have a genetic condition
  • The couple has a child or family history of serious genetic conditions

What does PGD test for?

The embryo can be tested for more than 100 genetic conditions using PGD. If the genetic conditions mentioned in the above section are considered sufficiently serious, the clinic may be permitted to check the embryo for that condition.

What clinics can offer PGD?

Clinics offering PGD need to have a specific license to do so. The license lets the clinic test an embryo for any single condition or combination thereof that is considered serious enough. Some clinics may be experienced in testing certain genetic conditions more than others.

Risks of PGD

The risks associated with PGD testing are the same as those of a conventional IVF cycle, but there are some additional risks like those given below:

  • The embryos may get damaged during the cell removal process
  • The testing may not be fully conclusive or reliable

The procedure

The procedure for Pre-implantation genetic diagnosis usually involves seven steps that are given below:

1. A conventional IVF cycle begins and the eggs are retrieved and fertilized by the male partner's sperm

2. The fertilized eggs are separated and placed in incubation. They develop into embryos, which are place in the lab for 48-72 hours until they reach the eight-cell stage.

3. The embryologist then removes a cell (blastomere) or two from the embryo

4. The cells undergo genetic testing to see if the embryos to which they belong contain the genetic condition(s) in the couple, couple's family, or couple's child.

5. Embryos that do not have the condition are separated. Some are transferred to the uterus for development

6. Other unaffected and separated embryos are cryogenically frozen for later IVF cycles. Embryos that have the genetic condition perish.

7. The woman undergoes a pregnancy test two weeks after the embryos are transferred

In some cases, the embryos may be allowed to grow for five-six days, at which point they will each have 100-150 cells that either form the placenta (trophectoderm) or the fetus (inner cell mass). Cells are removed from the trophectoderm without harming the embryo, which helps in getting more accurate results.

The chances of successful pregnancy after PGD

Lack of data associated with PGD makes it difficult to assess success rates, but most couples using this procedure do it because they want to avoid their child from suffering a genetic disease, and not for any fertility problem. Success, of course, depends on a lot of conditions like the woman's age and the cause of infertility, if any. Sometimes, there may not be any embryos suitable for transfer after PGD because:

  • All of them had the genetic disease
  • Removal of cells damaged the embryos
  • Not enough embryos were available

IVF Treatment in Turkey

Medicana International Hospital Istanbul

We offer a wide range of Assisted Reproductive Technologies includingIVFand ICSI (Intracytoplasmic Sperm Injection), Embryo and SpermCryopresevation, Intrauterine inseminations (IUI), ovulation induction, Co-Culture (Artificial Uterus). Also other micromanipulation methods (assisted hatching, defragmentation, blastomer biopsy), epididymal or testicular sperm aspiration/extraction (PESA, TESA, TESE or micro TESE) are carried out in our laboratory.

We generally prefer day 5 (blastocyct) transfer with high pregnancy rates, potential for very low multiple birth risks.. You will have the benefits of well-trained and English-speaking physicians and support personnel and what's more, you will pay just half the cost of comparable Western IVF clinics.

Let us help you to have a healthy new baby as soon as possible with no waiting list. We pride ourselves on giving this opportunity to even the most challenging of patients.

http://turkey-ivf.com/

24 Nisan 2013 Çarşamba

Intrauterine Insemination or In-vitro Fertilization?


As is known, the first approach for couples who do not have any evincible problem, in other words, were diagnosed with idiopathic infertility is intrauterine insemination for several times and then in-vitro fertilization treatments if no pregnancy occurs.

Read more:

http://turkey-ivf.com/ivf/intrauterine-insemination-or-in-vitro-fertilization.html

11 Nisan 2013 Perşembe

What is ivf 3d - ivf cost- ivf price - http://www.turkey-ivf.com





http://www.turkey-ivf.com

http://tinyurl.com/957dsfo

Medicana International Istanbul IVF Center
We offer a wide range of Assisted Reproductive Technologies includingIVF and ICSI (Intracytoplasmic Sperm Injection), Embryo and SpermCryopresevation, Intrauterine inseminations (IUI), ovulation induction, Co-Culture (Artificial Uterus). Also other micromanipulation methods (assisted hatching, defragmentation, blastomer biopsy), epididymal or testicular sperm aspiration/extraction (PESA, TESA, TESE or micro TESE) are carried out in our laboratory.We generally prefer day 5 (blastocyct) transfer with high pregnancy rates, potential for very low multiple birth risks.. You will have the benefits of well-trained and English-speaking physicians and support personnel and what's more, you will pay just half the cost of comparable WesternIVF clinics.Let us help you to have a healthy new baby as soon as possible with no waiting list. We pride ourselves on giving this opportunity to even the most challenging of patients. opportunity to even the most challenging of patients.
Web: http://www.turkey-ivf.com/ Phone: +90 212 867 79 18
Our Package Prices are as follows;
Option 1
IVF / ICSI Package
İncluding all exams, ultrasound, blood tests £ 1500
Freezing Excess Embriyos ( With Vitrification ) £ 250
Assiste Hatching ( With Laser) Included
IMSI ( In severe male factor cases) Included

All cycle costs are package costs and include all the ultrasound scans, anaesthetic charges, doctor's fees and post-op recovery where applicable.
At the time of egg collection, if there are no eggs or failed fertilisation, we refund £ 300 for cancellation of embryo transfer
Pregnancy scans are charged separately.
Medication costs are charged separately and can vary from patient to patient. Patients are requested to buy the drugs from the pharmacy themselves

Option 2

£ 2250 : Option 1 + all drugs and medications until embriyo transfer

Option 3

£ 3250 : Option 2 + freezing the extra embryos and also a 20 night accommodation in a flat and airport transfers. Flat is fully furnished and very near to our Hospital (in walking distance).


What are my chances of success from IVF?


Success rates of IVF treatment cycles depend on certain variables, which include the age of the woman,  number of eggs produced after stimulating the ovaries with fertility drugs, quality of the semen, number of good quality resulting embryos, and the number of transferred embryos.
IVF success rates are higher for women under 35. The success rates of in vitro fertilization can be increased by combining IVF with other treatment methods. IVF is often performed with ICSI to increase the success rates of fertilization during the IVF process.  

What is IVF?



IVF or In Vitro Fertilisation, refers to the most widely spread method of Assisted Reproductive Technology (ART). The Latin term 'in vitro' means anything that is cultivated outside a living organism - literally“in a glass.” Early biological experiments involving the cultivation of tissues outside their living organisms, were carried out in glass containers such as test tubes, petri dishes and beakers, hence the term “test tube baby.” 
During in vitro fertilisation, collected eggs are fertilized outside the womb and resulting embryos are transferred into the uterus of the woman. In the case of IVF with Egg Donation, the eggs of the donor are used for fertilization outside of the womb, and then the resulting embryo is transferred into the uterus of the female recipient.

What is IVF with ICSI (Intracytoplasmic Sperm Injection)?

The test-tube fertilization process has been replaced with ICSI (intracytoplasmic sperm injection) because of its proven success rates.
ICSI is the process by which one sperm is inserted into one egg, resulting in one embryo.
ICSI is more effective than IVF with a higher success rate because the sperm is injected directly into the cytoplasm of the egg stimulating the fertilization process.
ICSI requires only one sperm making it a successful treatment method for males with a low sperm count or poor quality sperm. 

6 Kasım 2012 Salı

SEVEN IMPORTANT FACTS YOU SHOULD KNOW ABOUT IVF AND THE CENTERS


The drive to have a family is a very strong natural urge in most individuals or couples, and its due to this that IVF treatments will continue to be an avenue for those in need of it, even in the face of many unanswered questions. When considering this as an avenue to explore or go down, one should know the answers of at least some of the main questions regarding IVF procedures and centers. Here are some examples..


1. What is the real success rate for IVF ?

Centres usually declare their success rates to be between 40 and 60 % per standard trial. However, in most circumstances what can influence or determine your success as an individual is you yourself. Each individual couple's chance of success depends on a number of varying factors such as age, cause of infertility and lifestyle etc. In general, for women in age groups below 35 years, each IVF trial has a success of 50 %. This significantly decreases over the age of 40 years, and for women at and over the age of 45 years, the chance is below 5% (with some exceptions).

It must be remembered however, that 'chance' always plays an important role in success. Our experience over the years has shown that for the vast majority of those who resisted and continued forging their way forward without losing their hope or confidence usually ended up with the joy of being hande d their babies at the end. Having said that, and regarding persistence, it's worth noting that if a couple or individual do not obtain success after three attempts in the same centre, then perhaps it's best attempting treatment at other centers. This is less to do with the failure of original centre, but more to do with enabling the couple or individual to make a psychological change.

2. Is IVF really expensive as they demand ?


Success certainly comes first, but the financial burden on the patient is often so great that many couples feel that they can only afford one cycle and therefore face the added stress of trying to maximize their one and only chance to conceive in that cycle, or get pregnant on the first try.

If you look at IVF prices in developed countries, it ranges between $10,000- $15,000 in US and 4500-5000GBP in UK per cycle. Besides, these prices do not cover the drug expenses and most centres charge the techniques ICSI, AHA, blastocyst culture etc. additionally. I recommend evaluating experienced centres with at least 50 cycles per month and over, to compare costs and make your selection then. On the other hand, countries like Turkey has affordable prices with high success rates. Expenses can be minimised to one-third of the high costs mentioned above and combining your medical treatment with a vacation in these countries is quite possible.

3. Is it harmful for my health ?

Every patient who is considering using IVF probably asks herself this question before she starts treatment. IVF treatment has been practiced for more than 30 years all over the world. Remember that more than four million IVF babies have been born since the earliest IVF successes in 1978. Lots of investigations have been carried out on the fact that IVF is a safe procedure when performed carefully. Today, as treatment is carried out by an experienced physician in a experienced centre, hardly a serious problem arise. Of course, as in any attempt to treat, unexpected problems and complications may occur in the rate of 1-2 %. These problems can be solved by a very large extent on careful observation and experience. The most common problem is the collection of fluid in the abdomen, bloating, excessive arousal table presenting the findings of the need for hospitalization called hyperstimulation syndrome and is about 1-2 % in experienced centres. Myths like IVF causes cancer are not at all true or based on medical findings .

4. You cannot change the age and capacity of your ovaries.

Every woman is most fertile between the ages of 20 and 30. Fertility starts to decline significantly from the age of 35. The decline in number of eggs with age is an important issue in IVF. However, egg quality and fertilization rates are also reduced from 35 years of age. There are several tests to help you to comment on that. AMH blood test (AMH) is a marker for ovarian reserve and provide information on the number of eggs to be obtained but not about the quality of the eggs. It is an indirect way of evaluating how well the ovaries are working.
Nature behaves differently in different individuals. So whilst on one hand one woman may have a wealth of ovarian capacity, another woman may unfairly suffer from the onset of menopause at an early age. The same situation is also true for men. Some may have hundreds of millions of sperm in their counts whilst some others may have very low or even none existent sperm in their counts. Unfortunately based on such a genetic characteristics, there is no specific treatment can be done. Remember that, you cannot produce new eggs and sperms, but in vitro fertilization treatment uses what exists. Perhaps this fact is subject to change with the development of stem cell therapies in the near future. We hope that this process will not take too long.

5. There is also physical and emotional cost of IVF treatment.

The majority of couples describe the IVF experience as financialy, physically and emotionally demanding. Physical side effects can include headaches, insomnia, bloating, fatigue and emotional fluctuations. Many also find the IVF experience stressful as they go through the painful process of waiting for the result. Reputable clinics offer specially trained psychological counselling services to help people through the emotionally challenging aspects of IVF. Of course, not every couple is requiring this services. In this regard, note that you are entitled to receive support and be ready for some amount of stress.

6. There is no guarantee.

Approximately four million children have been born worldwide as a result of in vitro fertilization treatments. It is a highly efficient technology to have a baby when the other treatment modalities are failed. According to statistics, around 85% of pregnancy rate reached after 3 attempts. However, with a good-quality embryo transfer in the best conditions, pregnancy rate is 50-55% per trial. In addition, miscarriage may occur in up to 10-15% in the age of 35. For a young lady trying IVF, take-home baby rate of a single embryo transfer in the optimum conditions for each trial is about 40 % . When much higher figures in the first interview is given to you, you should think about reliability of that centre.

IVF is a highly effective treatment in overcoming many causes of infertility such as low-sperm count, blocked fallopian tubes and PCOS. However, there are no guarantees. In fact, it is known that half of the people who try IVF will not be successful for each trial.

7. When should I give up?

In theory, as long as eggs from woman and the sperm from the man can be obtained and the transfer performed, the couple has a chance of pregnancy. However, if female age is close to 45, with three or more failed attempts, only poor quality embryos hardly obtained despite high-doses of drugs, and you start to get in trouble financially, sit down with your partner and think again.
Should you go on trying even your doctor say so ?
Doctors may be reluctant to stop treatment because they don’t want to accept “failure” on their part as a care-provider or they may feel that part of their job is to remain eternally hopeful and optimistic for you. The bottom line is that this is your and your partners decision.